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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway

Fig. 5

CircRNA_102171 activates Wnt/β-catenin pathway through promoting β-catenin-TCF/LEF interaction. a Western blot showed that circRNA_102171 knockdown inhibited β-catenin-TCF/LEF interaction while promoting CTNNBIP1/β-catenin interaction. b Western blot indicated that circRNA_102171 overexpression promotes β-catenin-TCF/LEF interaction while inhibiting CTNNBIP1/β-catenin interaction. c qRT-PCR showed that circRNA_102171 did not regulate CTNNBIP1 expression. d qRT-PCR showed that circRNA_102171 knockdown suppressed the expression of Wnt/β-catenin target genes (MYC/SOX4/CCND1/CCND2). e Western blot showed that higher expression of circRNA_102171 in PTC tissues was correlated with enhanced activation of Wnt/β-catenin pathway. Si-NC: siRNA negative control. si-circ: siRNA targeting circRNA_102171

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