Fig. 1
Expression of XIST and its correlation with the clinical parameters in patients with thyroid cancer (a) XIST expression in 512 thyroid cancer tissue samples and 337 adjacent non-tumor tissue samples based on the data from TCGA-THCA were exhibited. b XIST expression in 77 paired thyroid cancer tissue samples and adjacent non-tumor tissue samples was examined using real-time PCR assays. c The distribution of XIST expression fold-change shown as tumor/normal (log2). d XIST expression in tumor tissues grouping by TNM stages (I + II vs. III + IV). The data are presented as mean ± SD of three independent experiments. *P < 0.05, **P < 0.01. e Kaplan-Meier overall survival curves for 77 patients with thyroid cancer classified according to relative XIST expression level. (F) Receiver operating characteristic (ROC) curve showing the area under the curve (AUC) to analyze the sensitivity and specificity of XIST as a biomarker for thyroid cancer