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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: LncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling

Fig. 3

Screening and verification of candidate XIST downstream target miRNAs (a) The fold-change of down-regulated miRNAs in thyroid cancer compared to non-tumor tissue samples, showing as logFC and P values. b Candidate downstream miRNAs of XIST predicted by lnc Tar and the most down-regulated miRNAs reported by GSE73182. (c) The expression of the above candidate miRNAs was achieved by transfection of miRNA mimics, as confirmed using real-time PCR assays; XIST expression was then determined using real-time PCR assays. d miR-34a expression in 77 paired thyroid cancer and non-tumor tissue samples was examined using real-time PCR assays. The data are presented as mean ± SD of three independent experiments. **P < 0.01. e The correlation between miR-34a expression and XIST expression was analyzed using Spearman’s rank correlation analysis

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