Fig. 1

Molecular and cellular determinants. a Representative Western blot analysis performed at basal conditions, of LKB1 protein levels in all NSCLC NCI-H1299 isogenic clones (WT, S, K, KS). Ran was used as loading control. Three independent experiments were performed. b Growth curve of NSCLC isogenic clones. Cells were seeded at 10000 cells/mL in 6-well plates and counted every 24 h. Growth curves of the individual clones were plotted as number of cells at different time points and represented the average of three independent counts of three independent experiments. Statistical analysis was performed using two-way ANOVA test and Bonferroni post-test for multiple comparisons and is reported in the box below the figure. **p-value< 0.01, ***p-value< 0.001, ****p-value< 0.0001. No statistically significant differences were at 24 and 48 h