Fig. 7

Schematic overview summing up our findings. Schematic diagram depicting the enhanced metabolic activity of KS co-occurrence in relation to its heightened susceptibility to nutrient limited conditions relative to single K or S and parental background in NSCLC H1299 derived clones. Red arrow thickness refers to the rate of glycolysis exploitation, blue arrow thickness refers to the rate of glutaminolytic cascade. Green triangle highlights the association between increased metabolic addiction with sensitivity to nutrient deprivation in NSCLC H1299 clones harbouring WT, S, K, and KS oncological genotypes