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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: miR-296-5p suppresses EMT of hepatocellular carcinoma via attenuating NRG1/ERBB2/ERBB3 signaling

Fig. 7

Fra-2 is a key transcription factor for miR-296-5p-mediated HCC EMT. The mRNA (a) and protein levels (b) of AP-1 transcription factors in miR-296-5p-KD Huh7, miR-296-5p-OE MHCC97H cells and their negative control cells. (c) The changes of EMT-related molecules in miR-296-5p-KD Huh7 and miR-296-5p-NC MHCC97H cells after Fra-2 knockdown. (d) The protein levels of Fra-2, Slug and Zeb1 after U0126 incubation. (e) Schematic diagram of NRG1/ERBB /RAS/MAPK/Fra-2 axis inactivation and HCC EMT reversal induced by miR-296-5p overexpression. *p < 0.05, **p < 0.01, ***p < 0.001

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