Fig. 1

Downregulation of DMTN correlates with advanced progression and poorer prognosis in CRC. a, The expression of DMTN in CRC tissues and in normal colon tissues in the TCGA mRNA sequencing data. b, The relationship between DMTN expression and TNM stage in the TCGA data. c, GSEA analysis of the “KEGG_COLORECTAL CANCER” gene set in the low versus high expression group of DMTN in CRC. D, Western blot analysis of DMTN expression in 10 fresh human CRC tissues with different degrees of differentiation (N = normal, T = tumor). e, IHC analysis of DMTN expression in 200 paraffin-embedded archived human CRC tissues (representative results). f, g, h, Kaplan-Meier analyses of CRC patient outcomes with low versus high expression of DMTN in our data (Cohort A), GSE17538 (Cohort B) and GSE17538 (Cohort C) (P < 0.05, log-rank test). * P < 0.05