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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Hypermethylation of DMTN promotes the metastasis of colorectal cancer cells by regulating the actin cytoskeleton through Rac1 signaling activation

Fig. 5

Epigenetic regulation of the DMTN gene through changes in the methylation status of the gene promoter. a, Analysis of the deletion rate of the DMTN gene in CRC using the TCGA exon sequencing data. b, The expression of DMTN in CRC cells treated with 5-Aza-CdR by RT-PCR and western blot analysis. c, d, Detection of the degree of DMTN promoter methylation in 10 CRC tissues and the paired normal tissues through the bisulfite genomic sequence (BSP) assay (N = normal, T = tumor). e, The relationship between the expression of DMTN and the degree of DMTN promoter methylation based on the results of both RT-PCR and bisulfite genomic sequence (BSP) assay (T = tumor). The error bars represent the mean ± SD of 3 independent experiments, ** P < 0.01

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