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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma

Fig. 6

Curcumin suppressed STAT3 phosphorylation and induced apoptosis in ESCC PDX models. a The tumor tissues were analyzed by immunoblotting against p-STAT3 and STAT3. β-actin was used as an internal control. b Tumor tissues from each group were excised and prepared for HE staining (200×). c and d Tumor tissues from two PDX models (EG2 and EG37) were prepared for TUNEL assay as described in materials. e and f Tumor tissues from two PDX models (EG2 and EG37) were prepared for IHC analysis against p-STAT3, Cox2 and Caspase-3. g and h Statistical analysis of p-STAT3, Cox2 and Caspase-3 from (e) and (f). *p < 0.05, **p < 0.01

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