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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway

Fig. 5

a, b AGS cells were infected with all H. pylori strains at MOI of 200 for 6 h. Levels of YAP and CagA were assessed by Western blotting in AGS cells co-cultured with PMSS1 and its ΔcagA mutant 54 N (a) or 7.13 and its CagA mutant (b). c, d YAP and CagA levels were detected in MKN-45 cells. e Expression and localization of YAP (green) visualized by immunofluorescence. The blue-fluorescent DAPI was used for nuclear staining. f mRNA levels of YAP and YAP downstream target genes were assessed by qRT-PCR. Data for gene expression were the mean ± SEM of 3 independent experiments. g Representative Western blot for CagA and YAP in AGS cells transfected with the recombinant CagA protein

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