Fig. 8From: Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathwayThe proposed mechanism of H. pylori CagA-mediated promotion of gastric tumorigenesis. CagA+ H. pylori delivers CagA into gastric epithelial cells via T4SS where CagA induces oncogene YAP expression, increases nuclear translocation of YAP that elevates downstream gene expression. The H. pylori CagA-mediated activation of YAP then leads to enhanced EMT program, thereby further promoting gastric tumorigenesisBack to article page