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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway

Fig. 8

The proposed mechanism of H. pylori CagA-mediated promotion of gastric tumorigenesis. CagA+ H. pylori delivers CagA into gastric epithelial cells via T4SS where CagA induces oncogene YAP expression, increases nuclear translocation of YAP that elevates downstream gene expression. The H. pylori CagA-mediated activation of YAP then leads to enhanced EMT program, thereby further promoting gastric tumorigenesis

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