A schematic representation of obesity- and diabetes-associated pancreatic cancer. High fat/caloric intake results in accumulation of excess fat, which further leads to development of obesity. a. In obesity, adipose tissue releases free fatty acids (FFAs), which enter circulation and accumulate in the non-adipose tissues such as muscle, liver and pancreas that leads to insulin resistance and diabetes. b. Along with FFAs, adipokines, altered gut microbiota and inflammatory markers contribute to pancreatic cancer development through unknown mechanisms.