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Table 2 Multivariate cox regression analysis of factors associated with OS in ESCC

From: Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)

Variable Training group (n = 93) Test group (n = 102)
95% CI RR P 95% CI RR P
Sex (male vs. female) 0.194–1.405 0.522 0.198 0.268–1.214 0.570 0.145
Age (≤60 vs. > 60 years) 0.796–2.877 1.514 0.206 0.573–1.674 0.980 0.940
Tumor size (≤5 cm vs. > 5 cm) 0.667–2.119 1.189 0.558 0.396–1.229 0.698 0.213
Tumor stages (T1 + T2 vs. T3+ T4) 0.643–3.247 1.445 0.373 0.555–2.548 1.189 0.656
Histologic grade (Well/ moderate
vs. Poor/NS)
0.880–3.517 1.759 0.110 0.491–1.852 0.954 0.889
Lymph node metastasis
(negative vs. positive)
0.109–4.526 0.702 0.709 0.306–1.951 0.773 0.586
Clinical stages (I + II vs. III + IV) 0.297–12.497 12.806 0.487 0.616–4.530 1.670 0.314
miR-10b-3p expression levels
(Low vs. High)
1.355–7.062 3.093 0.007 1.678–7.913 3.644 0.001