Fig. 8
From: Dysregulation of miR-6868-5p/FOXM1 circuit contributes to colorectal cancer angiogenesis
miR-6868-5p is downregulated in human CRC and correlates with angiogenesis. a qRT-PCR was used to quantify expression of miR-6868-5p in 14 pairs of CRC tissues and adjacent normal tissues. b The shaded squares in the upper right showed Spearman correlation values between the expression of indicated genes in CRC tissues. The lower left squares show the scatter plot and fitted trend lines for the same comparisons. ** Correlation is significant at the 0.01 level. c Representative view of immunostaining of CD31, FOXM1 and IL-8 in CRC tissue sections with high or low miR-6868-5p expression. Scale bars = 20 μm. d Schematic representation of the mechanism of miR-6868-5p/FOXM1circuit in the regulation of CRC angiogenesis