Disease | Agents | Targets | Mechanisms of necroptosis | Ref |
---|---|---|---|---|
AML | Birinapant+Emricasan | cIAPs, caspase-8 | TNFR1 signaling; RIPK1/RIPK3/MLKL dependent | [123] |
BV6+zVAD-fmk | cIAPs, pan-caspase | RIPK1/RIPK3/MLKL dependent; autocrine TNF-α | [124] | |
BV6+Cytarabine | cIAPs, DNA synthesis | RIPK1/RIPK3/MLKL dependent; autocrine TNF-α | [125] | |
BV6+Azacitidine or Decitabine | cIAPs, DNA methylation | RIPK1/RIPK3/MLKL dependent; autocrine TNF-α | [126] | |
BV6+MS275 or SAHA | cIAPs, Histone deacetylase | RIPK1/RIPK3/MLKL dependent; autocrine TNF-α | [127] | |
HXR9 | HOX/PBX dimer | RIPK1 dependent | [133] | |
Diphtheria toxin GM-CSF | Protein synthesis | RIPK1 dependent | [137] | |
Erastin | Unknown | RIPK3 dependent; c-JNK and p38 dependent | [138] | |
ALL | BV6+Dexamethasone | cIAPs, Glucocorticoid receptor | RIPK1/RIPK3/MLKL activation; Bak activation and mitochondrial perturbation | [143] |
BV6, LCL161, Birinapant | cIAPs | RIPK1/RIPK3/MLKL dependent; autocrine TNF-α; enhanced by hyperosmotic stress | [145] | |
BV6 + Azacytidine | cIAPs, DNA methylation | RIPK1/RIPK3/MLKL-dependent; autocrine TNF-α | [145] | |
Obatoclax | Bcl-2 | Autophagy-dependent; mediated by RIPK1, CYLD | ||
MG132, Bortezomib | Proteasome | RIPK3/MLKL dependent; accumulation of polyubiquitinated RIPK3 | [154] | |
CLL | Ethacrynic acid | LEF1 | CYLD activation | |
CML | LQFM018 | Unknown | TNFR1 and CYLD upregulation; involvement of dopamine D4 receptor | [165] |
Pig7 | Lysosomal | MLKL activation; alteration of MMP and ROS levels | [167] |