Table 1 Relationship between IMPDH2 expression level and clinical pathological parameters of CRC

Characteristics

n = 214

Low (%)

High (%)

P value

x²

Gender

0.083

3.014

 Male

136

60(44.1)

76(55.9)

 Female

78

25(32.1)

53(67.9)

Age (years)

0.154

2.033

 <55

106

37(34.9)

69(65.1)

 ≥ 55

108

48(44.4)

60(55.6)

Tumor site

0.626

0.936

 Proximal colon

47

17(36.2)

30(63.8)

 Distal colon

37

13(35.1)

24(64.9)

 Rectum

130

55(42.3)

75(57.7)

Tumor size (cm)

0.253

1.305

 <5

116

42(36.2)

74(63.8)

 ≥ 5

98

43(43.9)

55(56.1)

Tumor differentiation

0.758

0.554

 Well

81

34(42.0)

47(58.0)

 Moderate

101

40(39.6)

61(60.4)

 Poor

32

11(34.4)

21(65.6)

T stage

0.048

6.057

 T1–2

59

31(52.5)

28(47.5)

 T3

140

50(35.7)

90(64.3)

 T4

15

4(26.7)

11(73.3)

Lymph node state

< 0.001

13.525

 Positive

88

22(25.0)

66(75.0)

 Negative

126

63(50.0)

63(50.0)

Distant metastasis

0.026

4.962

 Positive

38

9(23.7)

29(76.3)

 Negative

176

76(43.2)

100(56.8)

Lymphovascular invasion

0.018

5.551

 Positive

73

21(28.8)

52(71.2)

 Negative

141

64(45.4)

77(54.6)

Clinical stage

0.001

15.697

 1

53

29(54.7)

24(45.3)

 2

63

31(49.2)

32(50.8)

 3

60

16(26.7)

44(73.3)

 4

38

9(23.7)

29(76.3)