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Table 2 Univariate and multivariate Cox regression analysis of prognostic factors in 214 CRC patients for overall survival

From: IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways

Variable

Univariate analysis

 

Multivariate analysis

HR

95% CI

P-value

 

HR

95% CI

P-value

Overall survival

 Gender

1.257

0.878–1.800

0.211

    

 Age (years)

0.900

0.632–1.282

0.559

    

 Tumor site

0.963

0.777–1.193

0.730

    

 Tumor size(cm)

0.792

0.553–1.136

0.205

    

 Tumor differentiation

1.187

0.915–1.539

0.197

    

 Lymph node state

2.673

1.867–3.826

< 0.001

 

1.728

1.166–2.561

0.006

 Distant metastasis

6.534

4.285–9.961

< 0.001

 

4.993

3.198–7.796

< 0.001

 IMPDH2 expression

2.427

1.633–3.607

< 0.001

 

1.891

1.248–2.866

0.003