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Table 2 Univariate and multivariate Cox regression analysis of prognostic factors in 214 CRC patients for overall survival

From: IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways

Variable Univariate analysis   Multivariate analysis
HR 95% CI P-value   HR 95% CI P-value
Overall survival
 Gender 1.257 0.878–1.800 0.211     
 Age (years) 0.900 0.632–1.282 0.559     
 Tumor site 0.963 0.777–1.193 0.730     
 Tumor size(cm) 0.792 0.553–1.136 0.205     
 Tumor differentiation 1.187 0.915–1.539 0.197     
 Lymph node state 2.673 1.867–3.826 < 0.001   1.728 1.166–2.561 0.006
 Distant metastasis 6.534 4.285–9.961 < 0.001   4.993 3.198–7.796 < 0.001
 IMPDH2 expression 2.427 1.633–3.607 < 0.001   1.891 1.248–2.866 0.003