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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: TNF-alpha and metalloproteases as key players in melanoma cells aggressiveness

Fig. 2

Characterization of A375 and SK-MEL-28, respectively, the most and the less aggressive model of human melanoma cell lines. a Cell proliferation after 24 h of serum deprivation. A375, under an extreme growing condition, showed a significantly (**P < 0.001) higher growth rate than SK-MEL-28. Data are expressed as percent of 61,143 cells for SK-MEL-28 and 60,212 cells for A375 and represent the mean ± SD of three experiments carried out in triplicate. b Invasion ability of melanoma cell lines by Boyden chamber assay. A375 were significant able to invade in respect to SK-MEL-28 (**p < 0.001); in particular, a mean of 42 and 5 cell per field were counted respectively). c Microphotographs showing forming spheroid capability. d The panel indicates the quantification of total cell number forming A375 and SK-MEL-28 spheroids (§ p < 0.0001)

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