Fig. 2
From: Targeted radiotherapy of pigmented melanoma with 131I-5-IPN
a In vitro cell uptake of 131I-5-IPN by pigmented B16F10 cells and amelanotic A375 cells at 1, 3, and 6 h. The uptake of 131I-5-IPN showed a time-dependent increase trend in B16F10 cells (*P < 0.001). The uptakes of 131I-5-IPN in B16F10 cells were significantly higher than those in A375 cells at all time points (*P < 0.001). b Blocking study of 131I-5-IPN pretreated with nonradiolabeled I-5-IPN in B16F10 cells and A375 cells. The uptake of 131I-5-IPN showed statistical decreased in B16F10 cells after pretreated with 1000-fold non-radioactive I-5-IPN (*P < 0.001)