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Table 1 Biodistribution of 131I-5-IPN in B16F10 melanoma bearing C57BL/6 mice and A375 melanoma bearing BALB/C-nu/nu mice at different time pi. (% ID/g, mean ± SD)

From: Targeted radiotherapy of pigmented melanoma with 131I-5-IPN

  B16F10 melanoma (n = 5) Blocked B16F10 melanoma (n = 5) A375 melanoma (n = 5)
1 h 6 h 24 h 48 h 72 h 1 h 1 h
Organ
 Blood 4.05 ± 1.06 1.44 ± 0.35 0.05 ± 0.01 0.04 ± 0.02 0.03 ± 0.03 0.07 ± 0.02 0.09 ± 0.02
 Brain 0.94 ± 0.21 0.11 ± 0.01 0.02 ± 0.02 0.01 ± 0.01 0.01 ± 0.00 0.06 ± 0.01 0.04 ± 0.02
 Heart 2.20 ± 0.38 0.47 ± 0.11 0.24 ± 0.16 0.06 ± 0.05 0.04 ± 0.04 0.11 ± 0.03 0.15 ± 0.05
 Lungs 5.82 ± 4.34 1.35 ± 0.18 0.36 ± 0.17 0.27 ± 0.09 0.08 ± 0.10 0.16 ± 0.03 0.19 ± 0.04
 Liver 19.81 ± 0.38 4.12 ± 0.30 1.53 ± 0.25 0.82 ± 0.28 0.46 ± 0.48 1.35 ± 0.20 1.52 ± 0.25
 Spleen 4.06 ± 1.50 0.87 ± 0.09 0.39 ± 0.26 0.33 ± 0.30 0.05 ± 0.06 0.34 ± 0.15 0.11 ± 0.02
 Kidney 5.87 ± 1.74 1.14 ± 0.15 0.18 ± 0.07 0.11 ± 0.04 0.05 ± 0.03 0.61 ± 0.53 0.17 ± 0.01
 Stomach 5.22 ± 1.55 2.24 ± 1.43 0.08 ± 0.02 0.11 ± 0.10 0.05 ± 0.03 0.17 ± 0.09 0.51 ± 0.28
 Large intestine 3.43 ± 0.52 0.72 ± 0.36 0.11 ± 0.06 0.06 ± 0.06 0.05 ± 0.06 0.29 ± 0.07 0.17 ± 0.04
 Small intestine 3.56 ± 0.40 0.79 ± 0.47 0.05 ± 0.01 0.05 ± 0.03 0.02 ± 0.01 0.38 ± 0.18 0.18 ± 0.03
 Muscle 1.18 ± 0.33 0.28 ± 0.03 0.02 ± 0.02 0.01 ± 0.00 0.02 ± 0.01 0.07 ± 0.02 0.17 ± 0.04
 Bone 3.24 ± 1.50 0.65 ± 0.08 0.12 ± 0.03 0.56 ± 0.89 0.04 ± 0.07 0.16 ± 0.01 0.17 ± 0.05
 Tumor 16.37 ± 3.32 14.33 ± 3.30 7.41 ± 2.21 4.26 ± 1.36 3.31 ± 1.45 2.67 ± 1.16 0.15 ± 0.12
 Thyroid 6.51 ± 2.13 1.36 ± 0.17 0.11 ± 0.04 0.08 ± 0.05 0.04 ± 0.06 0.29 ± 0.08 0.25 ± 0.02
 Eyes 22.45 ± 4.74 15.02 ± 2.12 11.27 ± 0.90 9.77 ± 1.02 7.17 ± 0.96 4.66 ± 1.10 0.30 ± 0.02
Uptake ratio
 Tumor-to-blood 4.16 ± 0.74 10.04 ± 0.75 151.3 ± 64.35 132.9 ± 124.9 188.1 ± 110.9 50.56 ± 40.23 1.49 ± 1.02
 Tumor-to-liver 0.85 ± 0.18 3.47 ± 0.70 4.91 ± 1.65 5.45 ± 2.16 10.49 ± 5.01 1.96 ± 0.73 0.10 ± 0.07
 Tumor-to-muscle 14.53 ± 3.33 51.72 ± 13.58 248.4 ± 143.7 121.5 ± 66.76 123.4 ± 37.89 40.08 ± 16.20 0.82 ± 0.29