Fig. 6

Overexpression of KLF4 blocks SIRT6-induced NSCLC metastasis in vivo. a Mice were injected through the tail vein with control, SIRT6-expressing, and SIRT6/KLF4-coexpressing A549/luc cells. Images were taken at 6 weeks after cell injection. b Graphs show quantitation of tumor burdens determined by bioluminescence intensity. ^*P < 0.05; n = 5. c Histochemical images show metastatic lesions in the lung. Scale bar = 50 μm. d Quantification of metastatic lesions in the lung. ^*P < 0.05; n = 5. e A molecular model for the mechanism of SIRT6-mediated cancer invasion and metastasis