Table 1 Clinicopathological characteristics of CRCs in according to Fn abundance or recurrence status
Characteristics | All cases | Fn-low/negative | Fn-high | P value | Non-recurrence | Recurrence | P value |
|---|---|---|---|---|---|---|---|
|  | (n = 94) | (n = 73) | (n = 21) |  | (n = 49) | (n = 45) |  |
Age | 0.849 | Â | Â | 0.646 | |||
  ≥ 60 | 42(44.7%) | 33 (45.2%) | 9 (42.9%) |  | 23 (46.9%) | 19 (42.2%) |  |
 <60 | 52 (55.3%) | 40 (54.8%) | 12(57.1%) |  | 26 (53.1%) | 26(57.8%) |  |
Sex | 0.936 | Â | Â | 0.323 | |||
 Female | 41 (43.6%) | 32 (43.8%) | 9 (42.9%) |  | 19 (38.8%) | 22 (48.9%) |  |
 Male | 53 (56.4%) | 41 (56.2%) | 12 (57.1%) |  | 30 (61.2%) | 23 (51.1%) |  |
Tumor location | 0.051 | Â | Â | 0.079 | |||
 Rectum | 54 (57.4%) | 42 (57.5%) | 12 (57.1%) |  | 23 (46.9%) | 31 (68.9%) |  |
 Distal colon | 23 (24.5%) | 21 (28.8%) | 2 (9.5%) |  | 16 (32.7%) | 7 (15.6%) |  |
 Proximal colon | 17 (18.1%) | 10 (13.7%) | 7 (33.3%) |  | 10 (20.4%) | 7 (15.6%) |  |
Tumor size | 0.156 | Â | Â | 0.131 | |||
 >4 cm | 41 (43.6%) | 29 (39.7%) | 12(57.1%) |  | 25 (51.0%) | 16 (35.6%) |  |
  ≤ 4 cm | 53 (56.4%) | 44 (60.3%) | 9 (42.9%) |  | 24 (49.0%) | 29 (64.4%) |  |
Differentiation | 0.840 | Â | Â | 0.573 | |||
 Well/Moderate | 75 (79.8%) | 59 (80.8%) | 16 (76.2%) |  | 38 (77.6%) | 37 (82.2%) |  |
 Poor | 19 (20.2%) | 14 (19.2%) | 5 (23.8%) |  | 11 (22.4%) | 8 (17.8%) |  |
Vascular invasion | 0.874 | Â | Â | 0.003 | |||
 Positive | 30 (31.9%) | 23 (31.5%) | 7 (33.3%) |  | 9 (18.4%) | 21 (46.7%) |  |
 Negative | 64 (68.1%) | 50 (68.5%) | 14 (66.7%) |  | 40 (81.6%) | 24 (53.3%) |  |
Neural invasion | 0.808 | Â | Â | 0.029 | |||
 Positive | 22 (23.4%) | 18 (24.7%) | 4 (19.0%) |  | 7 (14.3%) | 15(33.3%) |  |
 Negative | 72 (76.6%) | 55 (75.3%) | 17 (81.0%) |  | 42 (85.7%) | 30 (6.7%) |  |
TNM stage | 0.130 | Â | Â | 0.153 | |||
 II | 45 (47.9%) | 38 (52.1%) | 7 (33.3%) |  | 20 (40.8%) | 25 (33.3%) |  |
 III | 49 (52.1%) | 35 (47.9%) | 14 (66.7%) |  | 29 (59.2%) | 20 (66.7%) |  |
BIRC3 staining | 0.008 | ||||||
 Positive | 36 (38.3%) | 21 (28.8%) | 15 (71.4%) | 0.000 | 25 (51.0%) | 11 (71.4%) |  |
 Negative | 58 (61.7%) | 52 (71.2%) | 6 (28.6%) |  | 24 (49.0%) | 34 (28.6%) |  |
TLR4 staining | 0.036 | ||||||
 Positive | 50 (53.2%) | 35 (47.9%) | 15 (71.4%) | 0.057 | 21 (42.9%) | 29 (64.4%) |  |
 Negative | 44 (46.8%) | 38 (52.1%) | 6 (28.6%) |  | 28 (57.1%) | 16 (35.6%) |  |
Fn abundance | 0.014 | ||||||
 Fn-low/negative | 73 (77.7%) |  |  |  | 43(83.6%) | 30 (71.1%) |  |
 Fn-high | 21 (22.2%) |  |  |  | 6 (16.4%) | 15 (28.9%) |  |