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Table 1 Clinicopathological characteristics of CRCs in according to Fn abundance or recurrence status

From: Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer

Characteristics All cases Fn-low/negative Fn-high P value Non-recurrence Recurrence P value
  (n = 94) (n = 73) (n = 21)   (n = 49) (n = 45)  
Age 0.849    0.646
  ≥ 60 42(44.7%) 33 (45.2%) 9 (42.9%)   23 (46.9%) 19 (42.2%)  
 <60 52 (55.3%) 40 (54.8%) 12(57.1%)   26 (53.1%) 26(57.8%)  
Sex 0.936    0.323
 Female 41 (43.6%) 32 (43.8%) 9 (42.9%)   19 (38.8%) 22 (48.9%)  
 Male 53 (56.4%) 41 (56.2%) 12 (57.1%)   30 (61.2%) 23 (51.1%)  
Tumor location 0.051    0.079
 Rectum 54 (57.4%) 42 (57.5%) 12 (57.1%)   23 (46.9%) 31 (68.9%)  
 Distal colon 23 (24.5%) 21 (28.8%) 2 (9.5%)   16 (32.7%) 7 (15.6%)  
 Proximal colon 17 (18.1%) 10 (13.7%) 7 (33.3%)   10 (20.4%) 7 (15.6%)  
Tumor size 0.156    0.131
 >4 cm 41 (43.6%) 29 (39.7%) 12(57.1%)   25 (51.0%) 16 (35.6%)  
  ≤ 4 cm 53 (56.4%) 44 (60.3%) 9 (42.9%)   24 (49.0%) 29 (64.4%)  
Differentiation 0.840    0.573
 Well/Moderate 75 (79.8%) 59 (80.8%) 16 (76.2%)   38 (77.6%) 37 (82.2%)  
 Poor 19 (20.2%) 14 (19.2%) 5 (23.8%)   11 (22.4%) 8 (17.8%)  
Vascular invasion 0.874    0.003
 Positive 30 (31.9%) 23 (31.5%) 7 (33.3%)   9 (18.4%) 21 (46.7%)  
 Negative 64 (68.1%) 50 (68.5%) 14 (66.7%)   40 (81.6%) 24 (53.3%)  
Neural invasion 0.808    0.029
 Positive 22 (23.4%) 18 (24.7%) 4 (19.0%)   7 (14.3%) 15(33.3%)  
 Negative 72 (76.6%) 55 (75.3%) 17 (81.0%)   42 (85.7%) 30 (6.7%)  
TNM stage 0.130    0.153
 II 45 (47.9%) 38 (52.1%) 7 (33.3%)   20 (40.8%) 25 (33.3%)  
 III 49 (52.1%) 35 (47.9%) 14 (66.7%)   29 (59.2%) 20 (66.7%)  
BIRC3 staining 0.008
 Positive 36 (38.3%) 21 (28.8%) 15 (71.4%) 0.000 25 (51.0%) 11 (71.4%)  
 Negative 58 (61.7%) 52 (71.2%) 6 (28.6%)   24 (49.0%) 34 (28.6%)  
TLR4 staining 0.036
 Positive 50 (53.2%) 35 (47.9%) 15 (71.4%) 0.057 21 (42.9%) 29 (64.4%)  
 Negative 44 (46.8%) 38 (52.1%) 6 (28.6%)   28 (57.1%) 16 (35.6%)  
Fn abundance 0.014
Fn-low/negative 73 (77.7%)     43(83.6%) 30 (71.1%)  
Fn-high 21 (22.2%)     6 (16.4%) 15 (28.9%)  
  1. Pearson Chi-square test