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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors

Fig. 4

Effects of SGI, MS275, or the combined treatment in bsMCF-luc, XtMCF, and LmMCF cell lines. a Combined treatment of SGI with MS275 significantly inhibits cell growth when compared with the single agent examined by MTT assay. b Tables show the IC50 of SGI and MS275, and the concentrations used for in vitro studies. c, e Quantification graphs for RTCA cell migration assay. d, f Quantification graphs for RTCA cell invasion assay. g Representative images of tumorspheres. Magnification, 40×. Scale bar, 100 μm. h Quantification of tumorshperes number. The tumorspheres formed by bsMCF-luc cells after the treatment with SGI or the combination were dissociated automatically and not counted

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