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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors

Fig. 5

MS275, or the combination of SGI with MS275 suppress TNBC growth or metastasis. a 5 × 104 XtMCF cells were injected to the mammary fat pad of 8–9 weeks old female CB17/SCID mice. Three days after cells injection, mice were treated with indicted compounds for three weeks. Mice were sacrificed 31 days post cells injection. Images of XtMCF xenografts are shown. Magnification, 6.3×. b Dot plot shows the tumor weight at sacrifice, the line in each group indicates the median value. c 8 × 104 LmMCF cells were injected into the tail vein of 8–9 weeks old female CB17/SCID mice. Six days after cells injection, mice were treated with vehicle control or MS275 once a week for three weeks. Mice were sacrificed 25 days post cells injection. Representative images of lungs fixed with Bouin’s solution show lung metastases on lung surface. Magnification, 8×. d Immunohistochemical staining to vimentin on lung sections show metastases of LmMCF cells in the lungs. Scale bar, 2 mm. e Quantification of the ratio of metastatic area to the whole lungs shows MS275 treatment inhibiting lung metastases of LmMCF cells

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