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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change

Fig. 2

Circ-DICER1 was up-regulated in GECs and knockdown of circ-DICER1 suppressed the viability, migration and tube formation of GECs in vitro. a The relative expression of circ-DICER1 in AECs and GECs was detected by qRT-PCR. Data represent means ± SD (n = 5, each group). **P < 0.01 vs. AECs group. b The relative expression of DICER1 was detected in AECs and GECs by qRT-PCR. GAPDH was used as an endogenous control. Data represent means ± SD (n = 5, each group). c The expression of circ-DICER1 in GECs with RNase R treatment. Data represent means ± SD (n = 5, each group). **P < 0.01 versus. Control group in AECs; ##P < 0.01 versus. RNase R group in AECs. d The mRNA expression of DICER1 in GECs with RNase R treatment. Data represent means ± SD (n = 5, each group). **P < 0.01 versus. Control group in AECs; ##P < 0.01 versus. Control group in GECs. e Effects of circ-DICER1 knockdown on the cell viability of GECs were detected by CCK-8 assay. Data are presented as the means ± SD (n = 5, each group). **P < 0.01 vs knockdown of circ-DICER1 NC group. f Effects of circ-DICER1 knockdown on the migration of GECs were detected by Transwell assay. Data are presented as the means ± SD (n = 5, each group). **P < 0.01 vs knockdown of circ-DICER1 NC group. Scale bar represents 30 μm. g Effects of circ-DICER1 knockdown on tube formation of GECs were measured by Matrigel tube formation assay. Data are presented as the means ± SD (n = 5, each group). **P < 0.01 vs knockdown of circ-DICER1 NC group. Scale bar represents 30 μm

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