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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis

Fig. 8

The miR-133a-3p-autophagy-glutaminolysis pathway distributes to a favorable environment for GC cells. (a). It was confirmed that the autophagy and glutaminolysis inhibition by siRNA and drug could further decrease survival abilities of LV-miR-133a-3p GC cells by clonogenic survival assay. (b). It was confirmed as well that the autophagy and glutaminolysis inhibition by siRNA and drug could further decrease mitochondrial respiration of LV-miR-133a-3p GC cells by oxygen consumption rate (OCR) assay. All data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001

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