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Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis

Fig. 9

The miR-133a-3p-autophagy-glutaminolysis pathway distributes to a favorable environment for GC cells. (a). ATP decreased greatly in LV-miR-133a-3p cells and was even lower in either autophagy or glutaminolysis deficient tumor cells, scale bar = 100 μm. (b). The deficiencies of autophagy and glutaminolysis made the low level of ROS in GC cells caused by LV-miR-133a-3p-IN become even lower. (c). Working pattern of miR-133a-3p regulating GC malignant behavior via autophagy mediated glutaminolysis. All data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001

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