Table 3 Characteristics of 85 NSCLC patients in Immunohistochemistry staining analysisa
From: Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis
Parameter | No. of patients | Low Slug (%) | High Slug (%) | P | Low Ubc9 (%) | High Ubc9 (%) | P |
|---|---|---|---|---|---|---|---|
Number of patients | 85 | 42 (49.4) | 43 (50.6) | 55 (64.7) | 30 (35.3) | ||
Age (mean±SD) | 63.4±9.9 | 62.6±10.0 | 64.2±9.8 | 0.4622 | 62.2±10.3 | 65.7±8.9 | 0.114b |
Sex | |||||||
Male | 53 | 30 (47.6) | 23 (39.0) | 31 (56.4) | 13 (43.3) | ||
Female | 69 | 33 (52.4) | 36 (61.0) | 0.336 | 24 (43.6) | 17 (56.7) | 0.251 |
Histological type | |||||||
Squamous cell carcinoma | 11 | 5 (11.9) | 6 (14.0) | 11 (2.0) | 0 (0.0) | ||
Adenocarcinoma | 68 | 32 (76.2) | 36 (83.7) | 41 (74.5) | 27 (90.0) | ||
Others | 6 | 5 (11.9) | 1 (2.3) | 0.225 | 3 (5.5) | 3 (10.0) | 0.028 |
Tumor size | |||||||
≤3cm | 33 | 16 (38.1) | 17 (39.5) | 21 (38.2) | 12 (40.0) | ||
>3cm | 52 | 26 (61.9) | 26 (60.5) | 0.892 | 34 (61.8) | 18 (60.0) | 0.869 |
Lymph node metastasis | |||||||
Negative | 39 | 18 (42.9) | 21 (48.8) | 23 (41.8) | 16 (53.3) | ||
Positive | 46 | 24 (57.1) | 22 (51.2) | 0.580 | 32 (58.2) | 14 (46.7) | 0.309 |
Tumor sizec | |||||||
Stage I | 30 | 15 (35.7) | 15 (34.9) | 24 (43.6) | 6 (20.0) | ||
Stage II | 32 | 15 (35.7) | 18 (41.9) | 18 (32.7) | 15 (50.0) | ||
Stage III–IV | 19 | 10 (23.8) | 9 (20.9) | 0.871 | 12 (21.8) | 7 (23.3) | 0.100 |
Slug expression | |||||||
Low | 30 (54.5) | 12 (40.0) | |||||
High | 25 (45.5) | 18 (60.0) | 0.200 | ||||
Ubc9 expression | |||||||
Low | 30 (71.4) | 25 (58.1) | |||||
High | 12 (28.6) | 18 (41.9) | 0.200 | ||||