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Table 3 Characteristics of 85 NSCLC patients in Immunohistochemistry staining analysisa

From: Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis

Parameter No. of patients Low Slug (%) High Slug (%) P Low Ubc9 (%) High Ubc9 (%) P
Number of patients 85 42 (49.4) 43 (50.6)   55 (64.7) 30 (35.3)  
Age (mean±SD) 63.4±9.9 62.6±10.0 64.2±9.8 0.4622 62.2±10.3 65.7±8.9 0.114b
Sex
Male 53 30 (47.6) 23 (39.0)   31 (56.4) 13 (43.3)  
Female 69 33 (52.4) 36 (61.0) 0.336 24 (43.6) 17 (56.7) 0.251
Histological type
Squamous cell carcinoma 11 5 (11.9) 6 (14.0)   11 (2.0) 0 (0.0)  
Adenocarcinoma 68 32 (76.2) 36 (83.7)   41 (74.5) 27 (90.0)  
Others 6 5 (11.9) 1 (2.3) 0.225 3 (5.5) 3 (10.0) 0.028
Tumor size
≤3cm 33 16 (38.1) 17 (39.5)   21 (38.2) 12 (40.0)  
>3cm 52 26 (61.9) 26 (60.5) 0.892 34 (61.8) 18 (60.0) 0.869
Lymph node metastasis
Negative 39 18 (42.9) 21 (48.8)   23 (41.8) 16 (53.3)  
Positive 46 24 (57.1) 22 (51.2) 0.580 32 (58.2) 14 (46.7) 0.309
Tumor sizec
Stage I 30 15 (35.7) 15 (34.9)   24 (43.6) 6 (20.0)  
Stage II 32 15 (35.7) 18 (41.9)   18 (32.7) 15 (50.0)  
Stage III–IV 19 10 (23.8) 9 (20.9) 0.871 12 (21.8) 7 (23.3) 0.100
Slug expression
Low      30 (54.5) 12 (40.0)  
High      25 (45.5) 18 (60.0) 0.200
Ubc9 expression
Low   30 (71.4) 25 (58.1)     
High   12 (28.6) 18 (41.9) 0.200    
  1. aP values were calculated using a two-sided Pearson Chi-Squared test. Slug and Ubc9 expression was designated as ‘high’ or ‘low’ using “50 and 60% immunoreactivity was shown in tumor sections” as the cut-off point respectively
  2. bP value was calculated using a Student’s t-test
  3. cThree patients’ tumor stage states were missing