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Table 4 Hazard ratios for death among patients with NSCLC based on protein expression levels as determined via immunohistochemistry and other parameters according to multivariate Cox regression analysisa

From: Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis

Parameter Hazard ratio (95% CI) P
High Slug and Ubc9 expression 5.08 (1.55 to 16.67) 0.007
Other expression profiles 2.15 (0.72 to 6.39) 0.168
Sex 2.45 (1.13 to 5.31) 0.023
Histological type 0.63 (0.23 to 1.70) 0.361
Tumor size 1.21 (0.96 to 1.51) 0.104
Tumor stage 0.94 (0.60 to 1.49) 0.800
  1. aA stepwise method was used to select the optimal multivariate Cox proportional hazard regression model. Slug and Ubc9 expression was designated as ‘high’ or ‘low’ using “50% and 60% immunoreactivity in the tumor sections” as the respective cut-off values (low Slug and low Ubc9 as the references). The results were adjusted according to sex (female as the reference vs. male), histological type (squamous cell carcinoma as the reference vs. adenocarcinoma), tumor size (≤ 3 cm as the reference vs. > 3 cm), and tumor stage. P values (two-sided) were calculated using a Pearson Chi-square test. Abbreviations: CI, confidence interval