Fig. 7

ARNTL increased sensitivity of nasopharyngeal carcinoma cells to cisplatin in vitro and vivo. a-d The CCK-8 assay revealed that overexpression of ARNTL increased cisplatin sensitivity while knocking down ARNTL decreased cisplatin sensitivity of SUNE1 and HONE1 cells in vitro. e, f Xenograft tumors of BALB/c nude mice at 18 days after injecting with Vector-overexpression or ARNTL-overexpression HONE1 cells and treating with cisplatin or saline. g Average tumor volume of BABL/c nude mice injecting with Vector-overexpression or ARNTL-overexpression HONE1 cells and treating with cisplatin or saline. h Tumor volume remission rates between Vector-overexpression and ARNTL-overexpression nude mice treated by cisplatin. i Average xenograft tumor weight of Vector-overexpression and ARNTL-overexpression nude mice treated by cisplatin or saline. j Tumor weight remission rates between Vector-overexpression and ARNTL-overexpression nude mice treated by cisplatin. * indicated P < 0.05; ** indicated P < 0.01