Fig. 7
From: SOX9 is a dose-dependent metastatic fate determinant in melanoma
SOXE and NEDD9 direct migration dynamics of melanoma cells. a Time-lapse imaging showing the migration dynamics and morphology of A375 cells treated with the indicated constructs and Lifeact-mCherry to mark actin cytoskeleton. White dotted lines indicate the border of the wound. Scale bars: 50 μM. b Quantification of the total speed of A375M cells treated with scramble control (n = 57), SOX10 KD (n = 52), NEDD9 (n = 51), SOX10 KD + SOX9 OE (n = 67) and SOX10 KD + NEDD9 OE (n = 38). Error bars represent mean ± SD of three independent experiments. p*** < 0.001