Fig. 4
From: Classification of triple-negative breast cancers based on Immunogenomic profiling
Identification of TNBC subtype-specific pathways, gene ontology, and networks. a. KEGG pathways enriched in Immunity_H and Immunity_L. b. The cancer-associated pathways upregulated in Immunity_H positively correlated with the immune scores, and the pathways upregulated in Immunity_L negatively correlated with the immune scores in TNBC (Spearman’s correlation test, P < 0.05). c. Gene modules significantly differentiating TNBC by subtype, survival time, or survival status. d. A network significantly active in Immunity_H, centered on five TFs (highlighted in red). e. A network significantly active in Immunity_L, centered on two TFs (highlighted in red). f. Kaplan–Meier curves showing that the expression of the hub TF genes is positively associated with survival prognosis in TNBC (log-rank test, P < 0.05). TF, transcription factor; FDR, false discovery rate