Fig. 4

Nuclear MET associates with p21 in cell cycle of single cells. a PC3 cells were immunostained with anti-p21, anti-MET antibodies and DAPI. Cell cycle undergoing cells were listed in differential phases. b A proposed summary and model that nMET induced p21 and cell self-clearance may not affect whole cell cycle of population but single cells may evolve via reprograming or be selected as a cancer stem cell for survival