Fig. 7
Nuclear receptor tyrosine kinases mediate poor prognosis based on database search and analysis. a The counted hits of reported clinical cohort studies were analyzed and most reported cases suggested the poor prognosis of nuclear localized RTKs compared to membrane RTKs. b A proposed model of nuclear RTK may through nuclear localization to clear unfitted dead cell to maintain membrane MET survival but may allow stem-like cells evolved to advanced recurrent cancer