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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: RNA sequencing reveals the expression profiles of circRNA and indicates that circDDX17 acts as a tumor suppressor in colorectal cancer

Fig. 4

CircRNA-miRNA interactions are potentially involved in the initiation and progression of CRC. a Network of circRNA-miRNA interactions potentially associated with the KEGG pathway of COLORECTAL CANCER. The network was based on the top 10 dysregulated circRNAs in CRC and their predicted target miRNAs with experimentally supported or in silico predicted target genes which were involved in the KEGG pathway of COLORECTAL CANCER. miRanda software was used to predict the target miRNAs of circRNAs, and miRPath software was used to identify miRNAs associated with the COLORECTAL CANCER pathway. The purple square node represented up-regulated circRNAs. The cyan square node represented down-regulated circRNAs. The red star node represented miRNAs associated with COLORECTAL CANCER pathway. The log2FC was represented by a color scale, increased from cyan (relatively lower log2FC) to purple (relatively higher log2FC). b The top 10 dysregulated circRNAs were potentially associated with the KEGG pathway of MicroRNAs in cancer (section of “Colorectal cancer”). Target miRNAs of top 10 dysregulated circRNAs were screened according to the KEGG pathway of MicroRNAs in cancer, and target miRNAs associated with the KEGG pathway of MicroRNAs in cancer were identified. Among the top 10 dysregulated circRNAs, circPRKAG2, circITGAL, circDDX17, circASPHD1, circSPIDR, and circHOMER1 could potentially bind to miRNAs involved in the KEGG pathway of MicroRNAs in cancer. Modified from the KEGG pathway map of MicroRNAs in cancer

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