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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: 14–3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling

Fig. 4

HO-1 is implicated in 14–3-3ζ-mediated tumor proliferation (a) 14–3-3ζ-overexpressing cells were stably transfected with shNC, or shHO-1 plasmids, to generate control (Vec-shNC) stable cells, 14–3-3ζ overexpressing (14–3-3ζ-shNC) stable cells, and 14–3-3ζ overexpressing but HO-1 knockdown (14–3-3ζ-shHO-1) stable cells. The expressions of HO-1 and 14–3-3ζ were examined by western blot analysis. b and c CCK8 assay and colony formation assay were performed for the indicated cells. d-f The indicated cells were subjected to an in vivo xenograft assay and tumor growth was assessed. d Photos of the xenograft tumors; e Tumor volume; f Tumor weights

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