Fig. 2

CXCR4^+/−Apc^min/+ compound mutant mice exhibited more tumor load than Apc^min/+ mice. a The schematic regimen of inflammatory cancer in Apc^min/+ and CXCR4^+/−Apc^min/+ mice by treatment with 3 cycles of 1% DSS. b Apc^min/+ and CXCR4^+/−Apc^min/+ mice (aged at 12 weeks, n = 15) were treated with or without 3 cycles of 1% DSS. At age of 30 weeks, the mice were sacrificed and representative images of intestine polyps were shown. c Average number and size of polyps of colon and small intestine were determined and statistical analysis was performed (n = 5 for each group). *P < 0.05 vs. Apc^min/+ mice. ^#P < 0.05 vs. Apc^min/+ and CXCR4^+/−Apc^{min/ +}mice respectively as indicated. d Representative H&E staining of colonic tumors (n = 5 for each group)