Fig. 5

Silencing of BTG2 expression reversed proliferation, invasion and migration of HCC cells. a, b Protein and mRNA levels of the BTG2 decreased after transfection with BTG2 shRNA into miR-6875-3p-silenced Huh7 cells, as demonstrated by Western blot and qRT-PCR. c Proliferation of Huh7 cells was reversed after transfection with BTG2 shRNA into miR-6875-3p-silenced Huh7 cells, as demonstrated by MTT assay. d, e and f Transwell and Wound-healing assay demonstrated that Silencing of BTG2 expression ameliorated down-regulated miR-6875-3p-induced suppression of Huh7 cell invasion and migration. Data are shown as the mean ± SD of three replicates (*p < 0.05)