Fig. 6

miR-6875-3p-BTG2 induced promotion of proliferation and migration through FAK/Akt pathway. a Supervised hierarchical clustering of the genes differentially expressed after BTG2 overexpression in Huh7 cells. b Gene-set enrichment analysis was carried out using ConceptGen. c Levels of the BTG2, phosphorylated FAK and phosphorylated Akt were detected using Western blot analysis. miR-6875-3p-silenced Huh7 cells were treated with shBTG2 RNA and Huh7 cells were treated with 10 μM of PF573228. d The proliferation-promoting effect of miR-6875-3p on Huh7 cells was blocked by PF573228, as demonstrated by an MTT assay. e, f and g The invasion and migration-promoting effect of miR-6875-3p on Huh7 cells was blocked by PF573228, as demonstrated by transwell and wound-healing assay. Data are shown as the mean ± SD of three replicates (*p < 0.05)