Fig. 4

The occurrence of oxidative stress in treated MCF7 cells. The comprehensive analysis of reactive oxygen species (ROS) generation included total ROS (a), mitochondrial ROS (mtROS) (b) superoxide (c) and antioxidative enzymes, namely, superoxide dismutases (SODs) (copper/zinc superoxide dismutase SOD1 and manganese superoxide SOD2) and catalase (d, e) after 3 days of treatment. * p < 0.05, difference relative to the control (Ctrl) group. # p < 0.05, difference relative to the Pep-1 group. + p < 0.05, difference between the Mito and P-Mito groups