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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: DHHC protein family targets different subsets of glioma stem cells in specific niches

Fig. 1

Expression of ZDHHC18 or ZDHHC23 is associated with tumor grade in gliomas. a Public data retrieved from the GENT database indicate that the expression levels of ZDHHC18 and ZDHHC23 are higher in brain cancer tissues (C) than those in normal brain tissues (N). The data were downloaded to normalized log2 value for each gene in the database and the graph was re-drawn in R program. (***, p < 0.001; Brain-N: n = 176, brain-C: n = 2357). b Expression levels of ZDHHC18 and ZDHHC23 as detected by western blot analysis in LGG, and GBM gliomas and normal brain tissues. β-actin was used as a loading control. NBT, normal brain tissue; LGG, low grade glioma; GBM, glioblastoma multiforme. c-e Quantification of ZDHHC18 mRNA expression levels in gliomas in TCGA (c), Rembrandt (d), and CGGA (e) datasets (ns, not significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001). f-h Quantification of ZDHHC23 mRNA expression levels in gliomas in TCGA (f), Rembrandt (g), and CGGA (h) datasets (*, p < 0.05; ***, p < 0.001). i and j Cumulative overall survival (i) and disease-free survival (j) of patients with GBM and low/high co-expression levels of ZDHHC18/ZDHHC23 (based on median expression levels of ZDHHC18 and ZDHHC23, respectively) estimated using the Kaplan–Meier method and compared with the log-rank test in the same set of patients (n = 32; *, p < 0.05; ***, p < 0.001)

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