Fig. 2

Expression of ZDHHC18 or ZDHHC23 is associated with glioblastoma (GBM) subgroups in patients with glioma. a Heatmap showing the expression pattern of ZDHHC18 and ZDHHC23 as indicated by Z-scores in distinct anatomic regions of GBM tissues from the Ivy GAP database (RNA-sample, n = 122; patient, n = 10). The corresponding histological feature for each RNA-sample is labeled as follows: leading edge (LE); infiltrating tumor (IT); cellular tumor (CT); perinecrotic zone (PZ); pseudopallisading cells around necrosis (PSEU); hyperplastic blood vessels in cellular tumor (HBV); microvascular proliferative region (MV). b and c Quantification of GBM subtype-specific ZDHHC18 expression in the TCGA and GSE4271 datasets. Log2-transformed values of the expression levels of ZDHHC18 mRNA are listed on the Y-axis. Error bars represent the SEM. d Receiver operating characteristic (ROC) curve showing sensitivity of ZDHHC18 as a marker to distinguish patients with mesenchymal from non-mesenchymal subtype GBM. e and f Quantification of GBM subtype-specific ZDHHC23 expression in the TCGA and GSE4271 datasets. Log2-transformed expression of ZDHHC23 mRNA levels is listed on the Y-axis. Error bars represent the SEM. g ROC curve showing the sensitivity of ZDHHC23 as a marker to distinguish patients with proneural from non-proneural subtype GBM. h Heatmap showing the expression pattern of ZDHHC18 and ZDHHC23 as indicated by Z-scores in the proneural and mesenchymal glioma cell lines from the GENT database (RNA-sample n = 266)