TY - JOUR AU - Rotte, A. AU - Bhandaru, M. AU - Zhou, Y. AU - McElwee, K. J. PY - 2015 DA - 2015// TI - Immunotherapy of melanoma: present options and future promises JO - Cancer Metastasis Rev VL - 34 UR - https://doi.org/10.1007/s10555-014-9542-0 DO - 10.1007/s10555-014-9542-0 ID - Rotte2015 ER - TY - JOUR AU - Wick, M. R. AU - Gru, A. A. PY - 2016 DA - 2016// TI - Metastatic melanoma: pathologic characterization, current treatment, and complications of therapy JO - Semin Diagn Pathol VL - 33 UR - https://doi.org/10.1053/j.semdp.2016.04.005 DO - 10.1053/j.semdp.2016.04.005 ID - Wick2016 ER - TY - JOUR AU - Xu, X. AU - Jin, Z. AU - Liu, Y. AU - Gong, H. AU - Sun, Q. AU - Zhang, W. PY - 2018 DA - 2018// TI - Carbohydrate-based adjuvants activate tumor-specific Th1 and CD8(+) T-cell responses and reduce the immunosuppressive activity of MDSCs JO - Cancer letters VL - 440–441 ID - Xu2018 ER - TY - JOUR AU - Hermel, D. J. AU - Ott, P. A. PY - 2017 DA - 2017// TI - Combining forces: the promise and peril of synergistic immune checkpoint blockade and targeted therapy in metastatic melanoma JO - Cancer Metastasis Rev VL - 36 UR - https://doi.org/10.1007/s10555-017-9656-2 DO - 10.1007/s10555-017-9656-2 ID - Hermel2017 ER - TY - JOUR AU - Boiko, A. D. AU - Razorenova, O. V. AU - Rijn, M. AU - Swetter, S. M. AU - Johnson, D. L. AU - Ly, D. P. PY - 2010 DA - 2010// TI - Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271 JO - Nature VL - 466 UR - https://doi.org/10.1038/nature09161 DO - 10.1038/nature09161 ID - Boiko2010 ER - TY - JOUR AU - Civenni, G. AU - Walter, A. AU - Kobert, N. AU - Mihic-Probst, D. AU - Zipser, M. AU - Belloni, B. PY - 2011 DA - 2011// TI - Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth JO - Cancer Res VL - 71 UR - https://doi.org/10.1158/0008-5472.CAN-10-3997 DO - 10.1158/0008-5472.CAN-10-3997 ID - Civenni2011 ER - TY - JOUR AU - Lobo, N. A. AU - Shimono, Y. AU - Qian, D. AU - Clarke, M. F. PY - 2007 DA - 2007// TI - The biology of cancer stem cells JO - Annu Rev Cell Dev Biol VL - 23 UR - https://doi.org/10.1146/annurev.cellbio.22.010305.104154 DO - 10.1146/annurev.cellbio.22.010305.104154 ID - Lobo2007 ER - TY - JOUR AU - Keshet, G. I. AU - Goldstein, I. AU - Itzhaki, O. AU - Cesarkas, K. AU - Shenhav, L. AU - Yakirevitch, A. PY - 2008 DA - 2008// TI - MDR1 expression identifies human melanoma stem cells JO - Biochem Biophys Res Commun VL - 368 UR - https://doi.org/10.1016/j.bbrc.2008.02.022 DO - 10.1016/j.bbrc.2008.02.022 ID - Keshet2008 ER - TY - JOUR AU - Meyer, M. AU - Gonzalez Deniselle, M. C. AU - Garay, L. AU - Sitruk-Ware, R. AU - Guennoun, R. AU - Schumacher, M. PY - 2015 DA - 2015// TI - The progesterone receptor agonist Nestorone holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration JO - Neuroscience VL - 308 UR - https://doi.org/10.1016/j.neuroscience.2015.09.007 DO - 10.1016/j.neuroscience.2015.09.007 ID - Meyer2015 ER - TY - JOUR AU - Uffort, D. G. AU - Grimm, E. A. AU - Ellerhorst, J. A. PY - 2009 DA - 2009// TI - NF-kappaB mediates mitogen-activated protein kinase pathway-dependent iNOS expression in human melanoma JO - J Invest Dermatol VL - 129 UR - https://doi.org/10.1038/jid.2008.205 DO - 10.1038/jid.2008.205 ID - Uffort2009 ER - TY - JOUR AU - Davies, H. AU - Bignell, G. R. AU - Cox, C. AU - Stephens, P. AU - Edkins, S. AU - Clegg, S. PY - 2002 DA - 2002// TI - Mutations of the BRAF gene in human cancer JO - Nature VL - 417 UR - https://doi.org/10.1038/nature00766 DO - 10.1038/nature00766 ID - Davies2002 ER - TY - JOUR AU - Wan, P. T. AU - Garnett, M. J. AU - Roe, S. M. AU - Lee, S. AU - Niculescu-Duvaz, D. AU - Good, V. M. PY - 2004 DA - 2004// TI - Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF JO - Cell VL - 116 UR - https://doi.org/10.1016/S0092-8674(04)00215-6 DO - 10.1016/S0092-8674(04)00215-6 ID - Wan2004 ER - TY - JOUR AU - Peyssonnaux, C. AU - Eychene, A. PY - 2001 DA - 2001// TI - The Raf/MEK/ERK pathway: new concepts of activation JO - Biol Cell VL - 93 UR - https://doi.org/10.1016/S0248-4900(01)01125-X DO - 10.1016/S0248-4900(01)01125-X ID - Peyssonnaux2001 ER - TY - JOUR AU - Poulikakos, P. I. AU - Zhang, C. AU - Bollag, G. AU - Shokat, K. M. AU - Rosen, N. PY - 2010 DA - 2010// TI - RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF JO - Nature VL - 464 UR - https://doi.org/10.1038/nature08902 DO - 10.1038/nature08902 ID - Poulikakos2010 ER - TY - JOUR AU - Yang, H. AU - Higgins, B. AU - Kolinsky, K. AU - Packman, K. AU - Bradley, W. D. AU - Lee, R. J. PY - 2012 DA - 2012// TI - Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer JO - Cancer Res VL - 72 UR - https://doi.org/10.1158/0008-5472.CAN-11-2941 DO - 10.1158/0008-5472.CAN-11-2941 ID - Yang2012 ER - TY - JOUR AU - Wagle, N. AU - Emery, C. AU - Berger, M. F. AU - Davis, M. J. AU - Sawyer, A. AU - Pochanard, P. PY - 2011 DA - 2011// TI - Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling JO - J Clin Oncol VL - 29 UR - https://doi.org/10.1200/JCO.2010.33.2312 DO - 10.1200/JCO.2010.33.2312 ID - Wagle2011 ER - TY - STD TI - Chan XY, Singh A, Osman N, Piva TJ. Role Played by Signalling Pathways in Overcoming BRAF Inhibitor Resistance in Melanoma. Int J Mol Sci. 2017;18(7):E1527. ID - ref17 ER - TY - JOUR AU - Corcoran, R. B. AU - Settleman, J. AU - Engelman, J. A. PY - 2011 DA - 2011// TI - Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers JO - Oncotarget VL - 2 UR - https://doi.org/10.18632/oncotarget.262 DO - 10.18632/oncotarget.262 ID - Corcoran2011 ER - TY - JOUR AU - Wang, A. X. AU - Qi, X. Y. PY - 2013 DA - 2013// TI - Targeting RAS/RAF/MEK/ERK signaling in metastatic melanoma JO - IUBMB Life VL - 65 UR - https://doi.org/10.1002/iub.1193 DO - 10.1002/iub.1193 ID - Wang2013 ER - TY - JOUR AU - McIsaac, W. M. AU - Farrell, G. AU - Taborsky, R. G. AU - Taylor, A. N. PY - 1965 DA - 1965// TI - Indole compounds: isolation from pineal tissue JO - Science VL - 148 UR - https://doi.org/10.1126/science.148.3666.102 DO - 10.1126/science.148.3666.102 ID - McIsaac1965 ER - TY - JOUR AU - Miles, A. AU - Philbrick, D. R. PY - 1988 DA - 1988// TI - Melatonin and psychiatry JO - Biol Psychiatry VL - 23 UR - https://doi.org/10.1016/0006-3223(88)90291-0 DO - 10.1016/0006-3223(88)90291-0 ID - Miles1988 ER - TY - JOUR AU - Slominski, R. M. AU - Reiter, R. J. AU - Schlabritz-Loutsevitch, N. AU - Ostrom, R. S. AU - Slominski, A. T. PY - 2012 DA - 2012// TI - Melatonin membrane receptors in peripheral tissues: distribution and functions JO - Mol Cell Endocrinol VL - 351 UR - https://doi.org/10.1016/j.mce.2012.01.004 DO - 10.1016/j.mce.2012.01.004 ID - Slominski2012 ER - TY - JOUR AU - Singh, M. AU - Jadhav, H. R. PY - 2014 DA - 2014// TI - Melatonin: functions and ligands JO - Drug Discov Today VL - 19 UR - https://doi.org/10.1016/j.drudis.2014.04.014 DO - 10.1016/j.drudis.2014.04.014 ID - Singh2014 ER - TY - JOUR AU - Beck-Friis, J. AU - Kjellman, B. F. AU - Aperia, B. AU - Unden, F. AU - Rosen, D. AU - Ljunggren, J. G. PY - 1985 DA - 1985// TI - Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome JO - Acta Psychiatr Scand VL - 71 UR - https://doi.org/10.1111/j.1600-0447.1985.tb02531.x DO - 10.1111/j.1600-0447.1985.tb02531.x ID - Beck-Friis1985 ER - TY - JOUR AU - Maestroni, G. J. AU - Conti, A. AU - Pierpaoli, W. PY - 1986 DA - 1986// TI - Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone JO - J Neuroimmunol VL - 13 UR - https://doi.org/10.1016/0165-5728(86)90047-0 DO - 10.1016/0165-5728(86)90047-0 ID - Maestroni1986 ER - TY - JOUR AU - Petranka, J. AU - Baldwin, W. AU - Biermann, J. AU - Jayadev, S. AU - Barrett, J. C. AU - Murphy, E. PY - 1999 DA - 1999// TI - The oncostatic action of melatonin in an ovarian carcinoma cell line JO - J Pineal Res VL - 26 UR - https://doi.org/10.1111/j.1600-079X.1999.tb00574.x DO - 10.1111/j.1600-079X.1999.tb00574.x ID - Petranka1999 ER - TY - JOUR AU - Grinevich, Y. A. AU - Labunetz, I. F. PY - 1986 DA - 1986// TI - Melatonin, thymic serum factor, and cortisol levels in healthy subjects of different age and patients with skin melanoma JO - J Pineal Res VL - 3 UR - https://doi.org/10.1111/j.1600-079X.1986.tb00749.x DO - 10.1111/j.1600-079X.1986.tb00749.x ID - Grinevich1986 ER - TY - JOUR AU - Alvarez-Garcia, V. AU - Gonzalez, A. AU - Alonso-Gonzalez, C. AU - Martinez-Campa, C. AU - Cos, S. PY - 2013 DA - 2013// TI - Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells JO - J Pineal Res VL - 54 UR - https://doi.org/10.1111/jpi.12007 DO - 10.1111/jpi.12007 ID - Alvarez-Garcia2013 ER - TY - JOUR AU - Jung, B. AU - Ahmad, N. PY - 2006 DA - 2006// TI - Melatonin in cancer management: progress and promise JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-06-1776 DO - 10.1158/0008-5472.CAN-06-1776 ID - Jung2006 ER - TY - JOUR AU - Wang, J. AU - Guo, W. AU - Chen, W. AU - Yu, W. AU - Tian, Y. AU - Fu, L. PY - 2013 DA - 2013// TI - Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways JO - J Pineal Res VL - 54 UR - https://doi.org/10.1111/jpi.12035 DO - 10.1111/jpi.12035 ID - Wang2013 ER - TY - JOUR AU - Cabrera, J. AU - Negrin, G. AU - Estevez, F. AU - Loro, J. AU - Reiter, R. J. AU - Quintana, J. PY - 2010 DA - 2010// TI - Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells JO - J Pineal Res VL - 49 ID - Cabrera2010 ER - TY - JOUR AU - Yun, M. AU - Kim, E. O. AU - Lee, D. AU - Kim, J. H. AU - Kim, J. AU - Lee, H. PY - 2014 DA - 2014// TI - Melatonin sensitizes H1975 non-small-cell lung cancer cells harboring a T790M-targeted epidermal growth factor receptor mutation to the tyrosine kinase inhibitor gefitinib JO - Cell Physiol Biochem VL - 34 UR - https://doi.org/10.1159/000366305 DO - 10.1159/000366305 ID - Yun2014 ER - TY - JOUR AU - Lu, J. J. AU - Fu, L. AU - Tang, Z. AU - Zhang, C. AU - Qin, L. AU - Wang, J. PY - 2016 DA - 2016// TI - Melatonin inhibits AP-2beta/hTERT, NF-kappaB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells JO - Oncotarget VL - 7 ID - Lu2016 ER - TY - JOUR AU - Kim, H. S. AU - Kim, T. J. AU - Yoo, Y. M. PY - 2014 DA - 2014// TI - Melatonin combined with endoplasmic reticulum stress induces cell death via the PI3K/Akt/mTOR pathway in B16F10 melanoma cells JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0092627 DO - 10.1371/journal.pone.0092627 ID - Kim2014 ER - TY - STD TI - Lee H, Lee HJ, Jung JH, Shin EA, Kim SH. Melatonin disturbs SUMOylation-mediated crosstalk between c-Myc and nestin via MT1 activation and promotes the sensitivity of paclitaxel in brain cancer stem cells. J Pineal Res. 2018;65(2):e12496. ID - ref35 ER - TY - JOUR AU - Chapman, P. B. AU - Hauschild, A. AU - Robert, C. AU - Haanen, J. B. AU - Ascierto, P. AU - Larkin, J. PY - 2011 DA - 2011// TI - Improved survival with vemurafenib in melanoma with BRAF V600E mutation JO - N Engl J Med VL - 364 UR - https://doi.org/10.1056/NEJMoa1103782 DO - 10.1056/NEJMoa1103782 ID - Chapman2011 ER - TY - JOUR AU - Ekmekcioglu, S. AU - Ellerhorst, J. A. AU - Prieto, V. G. AU - Johnson, M. M. AU - Broemeling, L. D. AU - Grimm, E. A. PY - 2006 DA - 2006// TI - Tumor iNOS predicts poor survival for stage III melanoma patients JO - Int J Cancer VL - 119 UR - https://doi.org/10.1002/ijc.21767 DO - 10.1002/ijc.21767 ID - Ekmekcioglu2006 ER - TY - JOUR AU - Greger, J. G. AU - Eastman, S. D. AU - Zhang, V. AU - Bleam, M. R. AU - Hughes, A. M. AU - Smitheman, K. N. PY - 2012 DA - 2012// TI - Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations JO - Mol Cancer Ther VL - 11 UR - https://doi.org/10.1158/1535-7163.MCT-11-0989 DO - 10.1158/1535-7163.MCT-11-0989 ID - Greger2012 ER - TY - JOUR AU - Joseph, E. W. AU - Pratilas, C. A. AU - Poulikakos, P. I. AU - Tadi, M. AU - Wang, W. AU - Taylor, B. S. PY - 2010 DA - 2010// TI - The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner JO - Proc Natl Acad Sci U S A VL - 107 UR - https://doi.org/10.1073/pnas.1008990107 DO - 10.1073/pnas.1008990107 ID - Joseph2010 ER - TY - JOUR AU - Wang, K. AU - Wu, X. AU - Wang, J. AU - Huang, J. PY - 2013 DA - 2013// TI - Cancer stem cell theory: therapeutic implications for nanomedicine JO - Int J Nanomedicine VL - 8 ID - Wang2013 ER - TY - JOUR AU - Till, J. E. AU - McCulloch, E. A. PY - 2012 DA - 2012// TI - A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. 1961 JO - Radiat Res VL - 178 UR - https://doi.org/10.1667/RRAV01.1 DO - 10.1667/RRAV01.1 ID - Till2012 ER - TY - JOUR AU - Alberti, L. AU - Renaud, S. AU - Losi, L. AU - Leyvraz, S. AU - Benhattar, J. PY - 2014 DA - 2014// TI - High expression of hTERT and stemness genes in BORIS/CTCFL positive cells isolated from embryonic cancer cells JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0109921 DO - 10.1371/journal.pone.0109921 ID - Alberti2014 ER - TY - JOUR AU - Zhang, K. AU - Guo, Y. AU - Wang, X. AU - Zhao, H. AU - Ji, Z. AU - Cheng, C. PY - 2017 DA - 2017// TI - WNT/beta-catenin directs self-renewal symmetric cell division of hTERT (high) prostate Cancer stem cells JO - Cancer Res VL - 77 UR - https://doi.org/10.1158/0008-5472.CAN-16-1887 DO - 10.1158/0008-5472.CAN-16-1887 ID - Zhang2017 ER - TY - JOUR AU - Seynnaeve, B. AU - Lee, S. AU - Borah, S. AU - Park, Y. AU - Pappo, A. AU - Kirkwood, J. M. PY - 2017 DA - 2017// TI - Genetic and epigenetic alterations of TERT are associated with inferior outcome in adolescent and young adult patients with melanoma JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/srep45704 DO - 10.1038/srep45704 ID - Seynnaeve2017 ER - TY - JOUR AU - Leon-Blanco, M. M. AU - Guerrero, J. M. AU - Reiter, R. J. AU - Pozo, D. PY - 2004 DA - 2004// TI - RNA expression of human telomerase subunits TR and TERT is differentially affected by melatonin receptor agonists in the MCF-7 tumor cell line JO - Cancer Lett VL - 216 UR - https://doi.org/10.1016/j.canlet.2004.05.003 DO - 10.1016/j.canlet.2004.05.003 ID - Leon-Blanco2004 ER - TY - JOUR AU - Hao, J. AU - Li, Z. AU - Zhang, C. AU - Yu, W. AU - Tang, Z. AU - Li, Y. PY - 2017 DA - 2017// TI - Targeting NF-kappaB/AP-2beta signaling to enhance antitumor activity of cisplatin by melatonin in hepatocellular carcinoma cells JO - Am J Cancer Res VL - 7 ID - Hao2017 ER - TY - JOUR AU - Wang, R. AU - Li, Y. AU - Tsung, A. AU - Huang, H. AU - Du, Q. AU - Yang, M. PY - 2018 DA - 2018// TI - iNOS promotes CD24(+)CD133(+) liver cancer stem cell phenotype through a TACE/ADAM17-dependent notch signaling pathway JO - Proc Natl Acad Sci U S A VL - 115 UR - https://doi.org/10.1073/pnas.1722100115 DO - 10.1073/pnas.1722100115 ID - Wang2018 ER - TY - JOUR AU - Puglisi, M. A. AU - Cenciarelli, C. AU - Tesori, V. AU - Cappellari, M. AU - Martini, M. AU - Francesco, A. M. PY - 2015 DA - 2015// TI - High nitric oxide production, secondary to inducible nitric oxide synthase expression, is essential for regulation of the tumour-initiating properties of colon cancer stem cells JO - J Pathol VL - 236 UR - https://doi.org/10.1002/path.4545 DO - 10.1002/path.4545 ID - Puglisi2015 ER -