Fig. 4

Dose-response studies of selected kinase inhibitors in non-cancer NHEM and NHDF cells. a Response to 3-fold serial dilutions of each kinase inhibitor was assessed 72 h after treatment by measuring cell viability. b The table indicates the half-maximal inhibitory concentrations (IC₅₀) for the selected inhibitors. The IC₅₀ values (nM) were calculated as indicated in Methods. Values represent the mean of at least three biological replicates. “n.e.”: not efficient: inhibitors did not suppress growth below 50% in the tested concentration range. “-”: values could not be determined in GraphPad. NHEM: normal human epidermal melanocytes; NHDF: normal human dermal fibroblasts