Fig. 2
From: miR-190 enhances endocrine therapy sensitivity by regulating SOX9 expression in breast cancer
Overexpression of miR-190 increases tamoxifen sensitivity in vivo. a, A total of 1 × 106 231-miR-190 or control cells were injected into the mammary fat pads of nude mice. When the tumor volume was ~ 100 mm3, the mice were divided into two groups and treated with tamoxifen and placebo, respectively. Representative photos of the tumors formed by 231-miR-190 or control cells at harvest time. b, Tumor volume of xenograft mice injected with 231-miR-190 (right) or control (left) cells treated with tamoxifen or placebo at the indicated times. c, The weights of tumors formed by 231- miR-190 or control cells treated with tamoxifen or placebo at harvest time. d, The expression of Ki-67 in tamoxifen- or placebo-treated xenograft tumors was examined by immunohistochemical staining. *P < 0.05