Fig. 1

Identification of hsa_circ_0000567 as a candidate biomarker of HCC. a Clustered heat map showed differentially expressed circRNAs in two paired HCC (T) and adjacent non-tumorous tissues (N). b-f The relative expression of three most upregulated circRNAs (hsa_circ_0005394, hsa_circ_0001741, hsa_circ_0006916) and two most downregulated circRNAs (hsa_circ_0000567, hsa_circ_0004058) were validated by qRT-PCR. g The relative expression of hsa_circ_0000567 in 132 HCC and 56 non-tumorous tissues. h and i Kaplan-Meier’s survival curves depicted the correlations between hsa_circ_0000567 and RFS or OS of HCC patients (the patients were stratified into two groups according to the median of hsa_circ_0000567). Log-rank test was used. For b-f, data are presented as means ± SD. HCC, hepatocellular carcinoma; T, tumor tissue; N, non-tumorous tissue; qRT-PCR, quantitative reverse transcription polymerase chain reaction; RFS, recurrence-free survival; OS, overall survival