Fig. 4
From: PRDM16 functions as a suppressor of lung adenocarcinoma metastasis
Effect of PRDM16 expression on the proliferation and invasiveness in xenograft mouse models. a, b and c, Subcutaneous injection of H1299 cells stably expressing EV or PRDM16 (screened by G418) into nude mice. The average tumor volume (p = 0.27) and weight (p = 0.19) were quantified. d, HE staining of tumor tissue of mice subcutaneously injected with H1299-EV and H1299-PRDM16 cells. e, Immunohistochemistry analysis of indicated key EMT-related markers and Ki67 in tumor tissue of mice subcutaneously injected with H1299-EV or H1299-PRDM16 (magnification: × 200). f, Pulmonary metastases of mice intravenously injected with H1299-EV/PRDM16 and Calu1-EV/PRDM16 cells