Fig. 9

Schematic diagram of the mechanism through which FAT4 inhibits the EMT and promotes autophagy in CRC via the PI3K/AKT/GSK-3β and PI3K/AKT/mTOR signaling pathways. Through the overexpression and silencing of FAT4 and PI3K, we demonstrated that FAT4 might negatively regulate PI3K to inhibit cancer development. In addition, FAT4 can inhibit the EMT by promoting autophagy and decreasing the level of Twist1