Skip to main content
Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: RETRACTED ARTICLE: Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the β-catenin/TCF4 pathway through SPRY2

Fig. 8

SPRY2 silencing reversed the suppressor effects induced by FOXO3a overexpression on EMT-associated migration and invasion of PDAC cells. a Wound healing assay was carried out to investigate the migratory ability of PANC-1 and SW1990 cells. b Transwell assay was applied to assess the migratory and invasive capacities of PANC-1 and SW1990 cells. c The protein expression of FOXO3a, SPRY2, β-catenin, TCF4, E-cad and VIM were detected in PANC-1 and SW1990 cells by Western blot. *P < 0.05, **P < 0.01, ***P < 0.001, ns non-significant

Back to article page