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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: CYT997(Lexibulin) induces apoptosis and autophagy through the activation of mutually reinforced ER stress and ROS in osteosarcoma

Fig. 7

CYT997 suppressed the growth of human osteosarcoma xenografts in vivo, and 3-MA could enhance the in vivo anti-tumor effect. a BALB/c-nu mice bearing 143B human orthotopic osteosarcoma xenografts were divided into four groups: [1] mice treated with PBS only, [2] mice treated with 3-MA only, [3] mice treated with CYT997 only and [4] mice treated with CYT997 plus 3-MA. CYT997 plus 3-MA showed more significant anti-tumor effects than did CYT997-only treatment. b Tumor weights of the tumors in the four groups were recorded. c The weight of mice in the two groups were recorded. d Levels of c-PARP, LC3B, p-eif2α, CHOP, and ERO1 in tumor xenograft tissues were measured by western blotting. e Immunohistochemical staining of tumor specimens. Scale bars = 50 μm *P < 0.05, significantly different compared with the control group

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